The Ryan Sims Foundation hosted its official unveiling on December 4, 2006 at Union Station in Kansas City, MO from 6:00 –  9:00 p.m. with an evening reception that included an art exhibit, live entertainment by KC’s own Heat Index, cocktails and hors d’oeuvres, and a silent auction.

Speakers included Cathleen Laporte, Executive Director of the Ryan Sims Foundation; Ryan Sims, Founder; Nichole Duvall, Executive Director of the American Cancer Society Hope Lodge; Karla Nichols, Executive Director of Cancer Action; Pastor Allen Dawkins of Believers' Fellowship AG; Brenda Sniezek, Community Relations Director of Kansas City Chiefs; and Carl Peterson, President of Kansas City Chiefs.  Al Wallace and John Holt of Fox 4 also made appearances at the event to show their support in the fight against cancer. The silent auction featured exclusive Kansas City Chiefs memorabilia and showcased portraits of Ryan Sims, Trent Green, Tony Gonzalez, Larry Johnson, Eddie Kennison, Brian Waters, Tamba Hali, and many others.  The silent auction was hosted by local radio personality, Sean Tyler of Hot 103 JAMZ and the Kansas City Chiefs Cheerleaders.

Sponsors included the Kansas City Cancer Center (Gold Tier), Kansas City Chiefs (Silver Tier), Believers' Fellowship AG (Bronze Tier), The Borowsky Group (Bronze Tier), Hot 103 JAMZ (Media), and KCSoul.com (Advertising). The event was open to the public and benefited Cancer Action and the American Cancer Society.